A Literature Review: Antimicrobial Phenolic Compounds in Nutmeg (Myristica fragrans Houtt)
Abstract
In various countries, testing of phenolic compounds in plants is always carried out because these compounds have various health benefits such as antioxidant, anti-inflammatory, and antimicrobial activities. The types of medicinal plants in Indonesia are known to be very diverse where those included in the medicinal plant group reach more than 1000 species, one of which is nutmeg (Myristica fragrans Houtt.) Nutmeg (Myristica fragrans Houtt.) itself is native to the Maluku Islands, Indonesia. However, besides the Moluccas, nutmeg is also cultivated in several other tropical countries. The main objective of this literature review is to critically examine the antimicrobial properties and identify the specific antimicrobial components of phenolic compounds contained in nutmeg (Myristica fragrans Houtt.) The methodology used in this study involved a comprehensive literature review by utilizing reputable academic databases such as Google Scholar, PubMed, and Science Direct related to articles published between 2019 and 2024. The results of this study were obtained through a thorough search process, resulting in eight articles that were considered to meet the established inclusion criteria. A number of articles showed the effectiveness of nutmeg as an antimicrobial because nutmeg contains phenolic compounds that have antibacterial and antifungal properties, which make it effective as an antimicrobial agent. Therefore, with a more comprehensive understanding of the content of phenolic compounds and their mechanism of action, nutmeg can be a further basis for study in the health sector and the pharmaceutical industry.
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Agaus, L. R., & Agaus, R. V. (2019). Manfaat Kesehatan Tanaman Pala (Myristica fragrans). Medula, 6(3), 662–666.
Arrizqiyani, T., Sumiati, S., & Meliansyah, M. (2018). Aktivitas Antibakteri Daging Buah dan Daun Pala (Myristica Fragrans) terhadap Escherichia Coli. Jurnal Vokasi Kesehatan, 4(2), 81. https://doi.org/10.30602/jvk.v4i2.119
Ashokkumar, K., Simal-Gandara, J., Murugan, M., Dhanya, M. K., & Pandian, A. (2022). Nutmeg (Myristica fragrans Houtt.) essential oil: A review on its composition, biological, and pharmacological activities. In Phytotherapy Research (Vol. 36, Issue 7, pp. 2839–2851). John Wiley and Sons Ltd. https://doi.org/10.1002/ptr.7491
Bayani, F., Kurniasari, B. A., Hamdani, A. S., Yuliana, D., Wahyuni, I., & Mujaddid, J. (2023). Identification of Secondary Metabolite Compounds from Melandean (Bridelian micrantha) Leaf Extract. Hydrogen: Jurnal Kependidikan Kimia, 11(6), 858–873. https://doi.org/10.33394/hjkk.v11i6.9879
Bayani, F., Muhali, M., Yuliana, D., Hulyadi, H., & Gargazi, G. (2024). Review of Secondary Metabolites From Melandean Bark Extract (Bridellia Micrantha): Bioactive Potential and Applications in Health. Hydrogen: Jurnal Kependidikan Kimia, 12(3), 413–428. https://doi.org/10.33394/hjkk.v12i3.11956
Biswas, D. (2022). The site of Anthropocene and colonial entanglement: Reviewing The Nutmeg’s Curse. Journal of Environmental Studies and Sciences, 12(4), 905–908. https://doi.org/10.1007/s13412-022-00783-9
Blessymol, B., Yasotha, P., Kalaiselvi, V., & Gopi, S. (2024). An antioxidant study of Titanium dioxide (TiO2) nanoparticles against mace of nutmeg in Myristica fragrans houtt, rhizomes of Curcuma longa linn and Kaempferia galanga extracts. Results in Chemistry, 7(December 2023), 101291. https://doi.org/10.1016/j.rechem.2023.101291
Dareda, C. T., Suryanto, E., & Momuat, L. I. (2020). Karakterisasi dan Aktivitas Antioksidan Serat Pangan dari Daging Buah Pala (Myristica fragrans Houtt). Chemistry Progress, 13(1), 48–55. https://doi.org/10.35799/cp.13.1.2020.29661
Fauziyah, E. V. A., & Kuswantoro, D. P. (n.d.). Prospek pengembangan pala (. 32–39.
Fibonacci, A., & Hulyadi, H. (2018). Uji Aktivitas Antimikroba Daun Sirsak (Annona muricata L.) Terhadap Bacillus subtillis dan Eschericia coli. Walisongo Journal of Chemistry, 1(1), Article 1. https://doi.org/10.21580/wjc.v2i1.2669
Ginting, B., Maira, R., . M., Helwati, H., Desiyana, L. S., & Mujahid, R. (2018). Isolation OF Essensial Oil of Nutmeg (Myristica fragrans Houtt) and Antioxidant Activity Test with DPPH. Jurnal Natural, 18(1), 11–17. https://doi.org/10.24815/jn.v18i1.6604
Handayani, S. W., Somadayo, N. A. S., Fiskia, E., & Nur, A. (2024). Efek Ekstrak Daging Buah Pala ( Myristica fragrans Houtt .) terhadap Histopatologi Pankreas Tikus Putih ( Rattus norvegicus ) Diabetes ( The Effect of Nutmeg ( Myristica fragrans Houtt .) Pulp Extract on The Pancreatic Histopathology Of Diabetic White Ra. 16(2), 84–91.
Hulyadi, H., Bayani, F., Muhali, M., Khery, Y., & Gargazi, G. (2023). Correlation Profile of Cognition Levels and Student Ability to Solve Problems in Biodiesel Synthesis. Jurnal Penelitian Pendidikan IPA, 9(6), Article 6. https://doi.org/10.29303/jppipa.v9i6.3130
Ismail, Y. S., Ulfa, A. H., Putri, I., Sutekad, D., & Fitri, L. (2024). Kemampuan Daya Hambat Ekstrak Buah Pala (Myristica fragrans H.) Terhadap Candida albicans. Jurnal Bioleuser, 8(1), 13–17. https://doi.org/10.24815/bioleuser.v8i1.37924
Kaawoan, P. T., Abidjulu, J., & Siagian, K. V. (2016). Uji daya hambat ekstrak buah pala (myristica fragrans Houtt) terhadap bakteri penyebab periodontitis porphyromonas gingivalis secara in vitro. E-GIGI, 4(2), 111–114. https://doi.org/10.35790/eg.4.2.2016.13504
Makanaung, E., Rorong, J. A., & Suryanto, E. (2021). Analisis Fitokimia dan Uji Efek Sedatif dari Ekstrak Etanol dan Beberapa Fraksi Daging Buah Pala (Myristica fragrans Houtt). Chemistry Progress, 14(1). https://doi.org/10.35799/cp.14.1.2021.34075
Melati Sirait, S., Enriyani, R., Studi Penjaminan Mutu Industri Pangan, P., AKA Bogor, P., Studi Analisis Kimia, P., AKA Bogor Jl Pangeran Sogiri No, P., Baru, T., Utara, B., Bogor, K., & Barat, J. (n.d.). Skrining Fitokimia dan Pengaruh Cara Pengeringan Terhadap Kualitas Ekstrak Etanol Daging Buah Pala (Myristica fragrans Houtt) (Vol. 45, Issue 2).
Nasir, Muh., & Marwati, E. (2022). Uji Aktivitas Antimikroba Ekstrak Etanol Daging Buah dan Daun Pala (Myristica fragrans). Jurnal Sains Dan Kesehatan, 4(SE-1), 67–76. https://doi.org/10.25026/jsk.v4ise-1.1691
Nikolic, V., Nikolic, L., Dinic, A., Gajic, I., Urosevic, M., Stanojevic, L., Stanojevic, J., & Danilovic, B. (2021). Chemical Composition, Antioxidant and Antimicrobial Activity of Nutmeg (Myristica fragrans Houtt.) Seed Essential Oil. Journal of Essential Oil-Bearing Plants, 24(2), 218–227. https://doi.org/10.1080/0972060X.2021.1907230
Nomor, V., Disi, M. Z. A., Fakhrur, M., Hi, R., & Rahman, I. (2024). Aktivitas Antioksidan dan Penentuan Kadar Total Flavonoid Fraksi Daging Buah Pala ( Myristica fragrans Houtt ). 6, 287–300.
Nurhasanah. (2014). Antimicrobial Activity Of Nutmeg (Myristica fragrans Houtt) Fruit Methanol Extract Againts Growth Staphylococus aureus and Escherichia coli. 3(1), 2301–4678.
Pashapoor, A., Mashhadyrafie, S., & Mortazavi, P. (2020). The Antioxidant Potential and Antihyperlipidemic Activity of Myristica fragrans Seed (Nutmeg) Extract in Diabetic Rats. Journal of Human, Environment, and Health Promotion, 6(2), 91–96. https://doi.org/10.29252/jhehp.6.2.7
Putri Anastasya, T., Runtuwene, M. R. J., & Suryanto, E. (2022). Aktivitas Antioksidan Ekstrak dan Fraksi Pelarut dari Cangkang Biji Pala (Myristica fragrans Houtt.). Chem. Prog, 15(1), 9–16.
Rahman, N., Mahmood, K., Kamilah, H., Sulaiman, S., Ibrahim, M., & Ariffin, F. (2022). Effects of blanching and pickling process on the alcohol acyltransferase (AAT) activity, myristicin content and quality parameters of pickled nutmeg (Myristica fragrans). Journal of Food Science and Technology, 59(2), 542–551. https://doi.org/10.1007/s13197-021-05038-z
Rashidian, G., Shahin, K., Elshopakey, G. E., Mahboub, H. H., Fahim, A., Elabd, H., Prokić, M. D., & Faggio, C. (2022). The Dietary Effects of Nutmeg (Myristica fragrans) Extract on Growth, Hematological Parameters, Immunity, Antioxidant Status, and Disease Resistance of Common Carp (Cyprinus carpio) against Aeromonas hydrophila. Journal of Marine Science and Engineering, 10(3). https://doi.org/10.3390/jmse10030325
Rizwana, H., Bokahri, N. A., Alkhattaf, F. S., Albasher, G., & Aldehaish, H. A. (2021). Antifungal, antibacterial, and cytotoxic activities of silver nanoparticles synthesized from aqueous extracts of mace-arils of myristica fragrans. Molecules, 26(24). https://doi.org/10.3390/molecules26247709
Rokhmah, N. N., Herlina, N., & Ananda, S. Y. (2024). Effectiveness of nutmeg flesh extract ( Myristica fragrans H ) as an immunomodulator using the carbon clearance method in mice ( Mus musculus ). 22(2), 297–306.
S. Aulia, and S. H. S. (2020). Diversifikasi Produk Olahan Buah Pala ( Myristica fragrans ) di Desa Sukadamai ( Diversification of Nutmeg ( Myristica fragrans ) Processed Products in Sukadamai Village ). J. Pusat Inovasi Masyarakat, 2(6), 966–972.
Shori, A. B. (2022). Storage quality and antioxidant properties of yogurt fortified with polyphenol extract from nutmeg, black pepper, and white pepper. Electronic Journal of Biotechnology, 57, 24–30. https://doi.org/10.1016/j.ejbt.2022.03.003
Simanjorang, T. M., Irham, Waluyati, L. R., & Mulyo, J. H. (2020). Comparative and competitive advantages of nutmeg farming in two regions in maluku province, indonesia. Biodiversitas, 21(3), 1165–1173. https://doi.org/10.13057/biodiv/d210342
Suhartini, W. (2022). Analisis Sensori Varian Minuman Pala (Myristica argentea Warb) yang dikombinasikan dengan Ekstrak Kopi (Coffea Canephora) dan Ekstrak Kayu Manis (Cinnamomum burmannii). Communication in Food Science and Technology, 1(1), 25. https://doi.org/10.35472/cfst.v1i1.958
Suloi, A. F., Nurmiati, N., & Wailussy, I. (2023). Pengaruh Konsentrasi Pelarut terhadap Kandungan Kimia Ekstrak Daging Buah Pala Fakfak (Myristica argentea Warb). Pro Food, 9(1), 82–88. https://doi.org/10.29303/profood.v9i1.284
Trifan, A., Zengin, G., Korona-Glowniak, I., Skalicka-Woźniak, K., & Luca, S. V. (2023). Essential Oils and Sustainability: In Vitro Bioactivity Screening of Myristica fragrans Houtt. Post-Distillation By-Products. Plants, 12(9). https://doi.org/10.3390/plants12091741
Usman, H., Rustini, R., Putri, L. E., & ... (2024). Formulasi dan Uji Aktivitas Gel Hand Sanitizer Ekstrak Etanol Daging Buah Pala (Myristica Fragrans Houtt) dalam Menghambat Pertumbuhan Staphylococcus Aureus. … of Education and …, 4(2).
Vakili, F., Roosta, Z., Safari, R., Raeisi, M., Hossain, M. S., Guerreiro, I., Akbazadeh, A., & Hoseinifar, S. H. (2023). Effects of dietary nutmeg (Myristica fragrans) seed meals on growth, non-specific immune indices, antioxidant status, gene expression analysis, and cold stress tolerance in zebrafish (Danio rerio). Frontiers in Nutrition, 9(January), 1–10. https://doi.org/10.3389/fnut.2022.1038748
Yam, J. H. (2024). Kajian Penelitian: Tinjauan Literatur Sebagai Metode Penelitian. Jurnal Empire, 4(1), 61–70.
DOI: https://doi.org/10.33394/hjkk.v13i1.14583
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