Antidiabetic Effect of Ethanol Extract of Keji beling Leaves (Strobhilantes crispa) in Rats Induced by Streptozotocin
Abstract
Diabetes Mellitus (DM) type 2 is a chronic disease characterized by increased glucose levels in the body due to insulin resistance or inadequate insulin production. This study aims to determine the antidiabetic potential of keji beling ( Strobhilantes crispa) leaf extract. This research is different from other studies which used Alloxan as a diabetes inducer. In this study, Streptozotocin was used as a DM inducer. After treatment, information was obtained that keji beling (S. crispa) extract could reduce blood glucose levels in type 2 DM rats. Experimental research used 30 male Wistar rats divided into six groups consisting of normal group, negative control (HFD and Streptozotocin), positive control (Glibenclamide), dose group I (150 mg/kg BW), dose II (300 mg/ kg BW), and dose III (450 mg/kg BW). Based on the research results, it is known that S.crispa leaf extract can reduce blood glucose levels in mice induced by Streptozotocin and has the potential to act as an antihyperglycemic in type 2 DM.
Keywords
Full Text:
PDFReferences
Andi Melvi Reski Ananda, Hasnaeni, Rezki Amriati ., Skripsi Pemisahan senyawa flavonoid pada tanaman keji beling (strobhilantes crispa), Fakultas Farmasi Universitas Muslim Indonesia
American Diabetes Association. (2017). Standards of medical care in diabetes 2017. Diabetes Care, 40(1), 1–8
Brata, A., Azizah, L., & Muin, D. (2023). The Effectiveness Of Using Bengkal Leaf Infusion (Nauclea Orientalis L.) As An Antidiabetic For Mice. Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health), 7(2), 75–81
Ghasemzadeh, A., Jaafar, H., Rahmat, A., (2015). Phytochemical constituents and biological activities of different extracts of Strobilanthes crispus (L.) Bremek leaves grown in different locations of Malaysia, 15 (422), 1-10
Hartanti, D., & Budipramana, K. (2020). Traditional antidiabetic plants from indonesia. Ethnobotany Research and Applications, 19(1), 1–12
Hasnaeni and Aminah. (2019). “Uji Aktivitas Antioksidan Dan Profil Fitokimia Ekstrak Kayu Beta-Beta (Lunasia Amara Blanco.).” Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 5(1): 101–7
IDF. (2021). International Diabetic Federation Diabetic Atlas 10th edition
Malingkay, H. P., Rumondor, R., & Walean, M. (2018). Uji efektifitas antidiabetes ekstrak etanol kulit buah manggis (Garcinia mangostana L) pada tikus putih (Rattus norvegicus) yang diinduksi aloksan. Chemistry Progress, 11 (1), 15– 20
Menant M., (1980). Medicinal plants of east and south east Asia. Cambridge, UK: MIT Pres
Natanael R, Aditya Y, widya A. L. 2017. Standarisasi Parameter Spesifik dan Uji Aktivitas Antikanker terhadap Sel Kanker Payudara T47D dari Ekstrak Etanol Daun Keji Beling (Strobilanthes crispa (L.) Blume). Pharmacon. 6: 181
Ojuade, F. I., Olorundare, O. E., Akanbi, O. B., Afolabi, S. O., & Njan, A. A. (2021). Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats. Heliyon, 7(6), 1–7
Palit, F., Tiwow, G., Maarisit, Wilmar., Karundeng, E., Karauwan, F. (2018). Uji aktivitas antidiabetes ekstrak etanol daun keji beling stobilanthes crispa blume pada tikus putih rattus norvegicus yang diinduksi aloksan., Jurnal Biofarmasetikal Tropis, 1 (1), 1-4
Panjuatiningrum, F., 2009. Pengaruh Pemberian Buah Naga Merah (Hylocereus polyrhizus) Terhadap Kadar Glukosa Darah Tikus Putih yang Diinduksi Aloksan, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta
Roussel, T. N. G., Martin, F., Aimé, Y. F. J., Lanvin, E. E. F. W., Boris, A. K., Laure, N. J., & Enyong, O. J. (2022). Antihyperglycemic and antihyperlipidemic activities of hydroethanolic extract of the fruit of Baillonella toxisperma in streptozotocin-induced diabetic rats. Metabolism Open, 15(2), 1–19
Ruswanto., Mardianingrum, R., Lestari, T., Nofianti, T., Tuslinah, L., Nurmalik, D. (2018). In silico study of the active compounds in bitter melon(Momordica charantia L) as antidiabeticmedication. Jurnal Pharmaciana, 8(2), 177-194
Samal, Pradeep Kumar. (2013). Antidiabetic and antioksidant activity of Strobilanthes asperrimus in rats. Journal of Global Trens In Pharmaceutical Seciences, 4(2): 1067-1072
Saputra, N. T., Suartha, I., Dharmayudha, A. A. G. O., (2018). Agen Diabetagonik Streptozotocin untuk Membuat Tikus Putih Jantan Diabetes Mellitus. Buletin Veteriner Udayana Volume 10 No. 22477-2712
Sun, J. W., Hernández-Díaz, S., Bourgeois, F. T., Haneuse, S., Brill, G., Bateman, B. T., & Huybrechts, K. F. (2021). Antidiabetic medication use in commercially insured children and adolescents in the United States from 2004 to 2019. Diabetes, Obesity and Metabolism, 23(2), 1–9
Ta Larasati., Meiwa, R., Putri, R. A. B., (2021). Uji Efektivitas Daun Keji Beling (Strobilanthes crispus [Sinonim=Sericocalyx crispus L]) sebagai Anti Diabetes Mellitus., Ilmu Kesehatan Komunitas, Fakultas Kedokteran, Universitas Lampung Fakultas Kedokteran, Universitas Lampung
DOI: https://doi.org/10.33394/hjkk.v12i5.13256
Refbacks
- There are currently no refbacks.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.