MEDICINAL EFFECT REVIEW OF AGARWOOD LEAVES FROM AQUILARIA AND GYRINOPS GENERA

I Gde Adi Suryawan Wangiyana

Abstract


Aquilaria and Gyrinops are the most common genera of Agarwood in Indonesia. These two group have wide distribution in Indonesia. Therefore, Indonesia is one of the biggest agarwood commodity producer in the world. However, the resin on agarwood stem is still main utilization of agarwood commodity in this country. Diversification agarwood utilization other than resin is needed to maximilize the potency of this commodity. Agarwood leaves are one of by product from agarwood cultivation that rarely been utilized. Agarwood leaves contain secondary metabolites that have medical effect such as Phenol, Flavonoid, Terpenoid , Alkaloid and Tannin. Thus, agarwood leaves has a good potency as a source of food and beverage product that have a medicinal effects. Agarwood leaves form Aquilaria group and Gyrinops group both have medicinal effect including antioxidant, antibacterial, cytotoxic and anticancer. Aquilaria leaves also has additional medicinal effect including: anti-inflammatory, anti-diabetic and laxative while Gyrinops leaves also has additional medicinal effect as antiradical source of sunscreen.

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Adam, A. Z., Lee, S. Y., & Mohamed, R., 2017. Pharmacological properties of agarwood tea derived from Aquilaria (Thymelaeaceae) leaves: An emerging contemporary herbal drink. Journal of Herbal Medicine, 10(2017), 37–44. https://doi.org/10.1016/j.hermed.2017.06.002

Akter, S., Islam, M. T., Zulkefeli, M., & Khan, S. I., 2013. Agarwood Production - A Multidisciplinary Field to be Explored in Bangladesh. International Journal of Pharmaceutical and Life Sciences, 2(1), 22–32. https://doi.org/10.3329/ijpls.v2i1. 15132

Antonopoulou, M., Compton, J., Perry, L. S., & Al-Mubarak, R., 2010. the Trade and Use of Agarwood (Oudh) in the United Arab Emirates. https://www.trafficj.org/public ation/10_Trade_Use_Agarwood. (Diakses: 2 Juni 2020)

Arrififin, N. M., Alimon, H., Sukari, M. A., Naz, H., 2013. Chemical study of Aquilaria crassna. Chem. Nat. Compd. 49, 575 – 576.

Azren, P. D., Lee, S. Y., Emang, D., & Mohamed, R., 2019. History and Perspectives of Induction Technology for Agarwood Production from Cultivated Aquilaria in Asia : A Review. Journal of Forestry Research, 30(1), 1–11. https://doi.org/10.1007/s11676-018-0627-4

Chen, C. H., Kuo, T. C. Y., Yang, M. H., Chien, T. Y., Chu, M. J., Huang, L. C., Chen, C. Y., Lo, H. F., Jeng, S. T., Chen, L. F. O., 2014. Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha. BMC Genomics, 15, 1 – 11.

Dash, M., Patra, J. K., Panda, P. P., 2008. Phytochemical and antimicrobial screening of extracts of Aquilaria agallocha Roxb. African Journal of Biotechnology. 7 (20), 3531 – 3534.

Duan, Z., Li, W., Dou, Z., Xie, H., He, A., Shi, M., 2015. Extraction and antioxidant activity of flavonoids from Aquilaria sinensis (Lour) Gilg leaves. J. Food Sci. 36, 45 – 50.

Feng, J., Yang, X. W., Wang, R. F., 2011. Bio-assay guided isolation and identification of α-glucosidase inhibitor from leaves of Aquilaria sinensis. Phytochmistry, 72, 242 – 247.

Hara, H., Ise, Y., Morimoto, N., Shimazawa, M., Ichihashi, K., Ohyama, M., & Iinuma, M., 2008. Laxative Effect of Agarwood Leaves and Its Mechanism. Bioscience, Biotechnology, and Biochemistry, 72(2), 335–345. https://doi.org/10.1271/bbb. 70361

Harahap, R. K., Batubara, R., & Surjanto., 2015. Uji Antioksidan Daun Muda dan Daun Tua Gaharu (Aquilaria malaccensis Lamk) Berdasarkan Perbedaan Tempat Tumbuh Pohon. Peronema Forestry Science Journal, 4 (4), 72–87.

Hendra, H., Moeljopawiro, S., & Nuringtyas, T. R., 2016. Antioxidant and antibacterial activities of agarwood (Aquilaria malaccensis Lamk.) leaves. AIP Conference Proceedings, 1755(14004). https://doi.org/10.1063/1.4958565

Ito, T., Kakino, M., Tazawa, S., Oyama, M., Maruyama, H., Araki, Y., Hara, H., Linuma, M., 2012. Identification of phenolic compounds in Aquilaria crassna leaves via liquid chromatography-electrospray ionization mass spectroscopy. Food Sci. Technol. Res., 18, 259 – 262.

Kakino, M., Hara, H., 2016. Pharmacological effects of Aquilaria spp. Leaves and their chemical constituents. In: Mohamed, R. (Ed.), Agarwood. Springer, Singapore, pp. 125 – 136.

Kakino, M., Sugiyama, T., Kunieda, H., Tazawa, S., Maruyama, H., 2012. Agarwood (Aquilaria crassna) extracts decrease high-protein highfat diet-induced intenstinal putrefaction toxins in mice. Pharm. Anal. Acta, 3: 152.

Kakino, M., Tazawa, S., Maruyama, H., Tsuruma, K., Araki, Y. Shimazawa, M., Hara, H., 2010. Laxative effects of agarwood on low-fiber diet-induced constipation in rats. BMC Complement. Altern. Med. 10, 1 – 8.

Kamonwannasit, S., Nantapong, N., Kumkrai, P., Luecha, P., Kupittayanant, S., & Chudapongse, N., 2013. Antibacterial activity of Aquilaria crassna leaf extract against Staphylococcus epidermidis by disruption of cell wall. Annals of Clinical Microbiology and Antimicrobials, 12(1), 1. https://doi.org/10.1186/1476-0711-12-20

Kang, Y. F., Chien, S. L., Wu, H. M., Li, W. J., Chen, C. T., Li, H. T., Chen, H. L., Chao, D., Chen, S. J., Huang, C. T., Chen, C. Y., 2014. Sceondary metabolites from the leaves of Aquilaria sinensis. Chem. Nat. Compd. 50, 1110 – 1112.

Karsiningsih, E., 2016. Analisis Kelayakan Finansial dan Strategi Pengembangan Teh Gaharu di Kabupaten Bangka Tengah (Studi Kasus: Teh Gaharu “Aqilla” Gapoktan Alam Jaya Lestari). AGRARIS: Journal of Agribusiness and Rural Development Research, 2(2), 143–151. https://doi.org/10.18196/agr.2235

Khalil, A. S., Rahim, A. A., Taha, K. K., Abdallah, K. B., 2013. Characterization of methanolic extracts of agarwood leaves. J. App. Ind. Sci. 1, 78 -–88.

Li, H., Jiang, Z., Mei, Q., 2013. Comparative study on the effect of Aquilaria sinensis leaf tea and agarwood on promoting small intestine propulsion. Asia-Pasific Tradit. Med. 9, 24 – 25

López-Sampson, A., & Page, T., 2018. History of Use and Trade of Agarwood. Economic Botany, 72(1), 107–129. https://doi.org/ 10.1007/s12231-018-9408-4

Mega, I., & Swastini, D., 2012. Screening Fitokimia Dan Aktivitas Antiradikal Bebas Ekstrak Metanol Daun Gaharu (Gyrinops versteegii). Jurnal Kimia, 4(2), 187–192.

Mei, Q., Li, H., Lin, H., Wu, X., Liang, L., Yang, H., Lan, Z., 2013. Comparative study on hypoglycemic effect between Aquilaria sinensis leaves and agarwood. Lishizhen Med. Mat. Med. Res. 24, 1606 – 1607.

Millaty, I. N. K., Wijayanti, N., Hidayati, L., & Nuringtyas, T. R., 2020. Identification of anticancer compounds in leaves extracts of agarwood ( Aquilaria malaccensis ( Lamk .)). IOP Conf. Series: Earth and Environmental Science, 1–8. https://doi.org/10.1088/1755-1315/457/1/012036

Naziz, P. S., Das, R., & Sen, S., 2019. The scent of stress: Evidence from the unique fragrance of agarwood. Frontiers in Plant Science, 10(840), 1–13. https://doi.org/10.3389/fpls.2019.00840

Nie, C., Song, Y., Chen, D., Xue, P., Tu. P., Wang, K. Chen, J. 2009. Studies on chemical constituents of leaves of Aquilaria sinensis. China J. Chin. Mater. Med., 34, 858 – 860

Nuringtyas, T. R., Isromarina, R., Septia, Y., Hidayati, L., Wijayanti, N., & Moeljopawiro, S., 2018. The antioxidant and cytotoxic activities of the chloroform extract of agarwood (Gyrinops versteegii (Gilg.) Domke) leaves on HeLa cell lines. AIP Conference Proceedings, 2002(020067), 1–9. https://doi.org/10.1063 /1.5050163

Parwata, A, Manuba, P., Yasa, S., & Bidura, I. G. N. G., 2016. Characteristics and Antioxidant Activities of Gaharu (Gyrinops versteegii) Leaves. Journal of Biological and Chemical Research, 33(1), 294–301.

Parwata, Adi, Manuaba, P., & Yasa, S., 2018. The potency of flavonoid compounds in water extract Gyrinops versteegii leaves as natural antioxidants sources. Biomedical and Pharmacology Journal, 11(3), 1501–1511. https://doi.org/10.13005/bpj/1517

Pranakhon, R., Pannangpetch, P., & Aromdee, C., 2011. Antihyperglycemic activity of agarwood leaf extracts in STZ-induced diabetic rats and glucose uptake enhancement activity in rat adipocytes rats and glucose uptake enhancement activity in rat adipocytes. Songklanakarin J. Sci. Technol., 33(4), 405–410.

Prihantini, A. I., & Rizqiani, K. D., 2019. Various antioxidant assays of agarwood extracts (Gyrinops versteegii) from West Lombok, West Nusa Tenggara, Indonesia. Asian Journal of Agriculture, 3(1), 1–5. https://doi.org/10.13057/asianjagric/g03101

Qi, J., Lu, J. J., Liu, J. H., Yu, B.Y., 2009. Flavonoid and a rare benxophenone glycoside from the leaves of Aquilaria sinensis. Chem. Pharm. Bull. 57, 134 – 137.

Rahman, H., Eswaraiah, M. C., Dutta, A. M., 2016. Anti-arthritic activity of leaves and oil of Aquilaria agallocha. Saudi J. Life Sci. 1, 34 – 43.

Roemantyo, & Partomihardjo, T., 2010. Analisis Prediksi Sebaran Alami Gaharu Marga Aquilaria dan Gyrinops di Indonesia. Berita Biologi, 10(2), 189–198.

Sari, R., Mutiara, M., Fakriaty, I., 2017. Uji aktivitas antibakteri ekstrak etanol daun gaharu (Aquilaria microcarpa Bail.) terhadap bakteri Staphylococcus aureus dan Proteus mirabilis. Pharm. Sci. Res. 4 (3), 143 – 154

Septia, Y., 2019. Antimetastasis ekstrak kloroform daun gaharu (Gyrinops versteegii (Gilg.) Domke) terhadap cell line kanker payudara T47D. Skripsi. Universitas Gadjah Mada. Yogyakarta

Siran, S. A., 2014. Gaharu Bioinduksi: Komoditi Elit Masa Depat Sektor Kehutanan. In A. Susmianto, M. Turjaman, & P. Setio (Eds.), Rekam Jejak Gaharu Inokulasi (2nd ed., pp. 17–32). FORDA Press.

Sun, J., Xia, F., Wang, S., Wang, K. Y., Chen, J. M., Tu, P. F., 2015. Structural elucidation of two new megastigmane glycosides from the leaves of Aquilaria sinensis. Chin. J. Nat. Med. 13, 0290 – 0294

Tan, C. S., Isa, N., Ismail, I., & Zainal, Z., 2019. Agarwood Induction : Current Developments and Future Perspectives. Frontiers in Plant Science, 10 (122), 1–13. https://doi.org/10.3389/fpls.2019.00122

Tay, P. Y., Tan, C. P., Abas, F., Yim, H. S., Ho, C. W., 2014. Assessment of extraction parameters on antioxidant capacity, polyphenol content, epigallocatechin gallate (EGGG), epicatechin gallate (ECG) and iriflophenone 3-C-β-glucoside of agarwood (Aquilaria crassna) young leaves. Molecule, 19, 12304 – 12319

Turjaman, M. & Hidayat, A., 2017. Agarwood- planted Tree Inventory in Indonesia. In: IOP Conference Series: Earth and Environmental Sciece. https://doi.org/ 10.1088/17551315/54/1/012062

Turjaman, M., 2014. Industri Hulu-Hilir Gaharu. In A. Susmianto, M. Turjaman, & P. Setio (Eds.), Rekam Jejak Gaharu Inokulasi (2nd ed., pp. 185–216). FORDA Press.

Wahid, A. R., & Ittiqo, D. H., 2019. Daya Hambat Bakteri Staphylococcus aureus Ekstrak Daun Gaharu (Aquilaria malea L.) Sebagai Antibakteri. Jurnal Insan Farmasi Indonesia, 2(1), 34–43. https://doi.org/ 10.1017/CBO9781107415324.004

Wahyuningrum, M., Sari, R. K., & Rafi, M., 2018. Aktivitas Antioksidan dan Tabir Surya Ekstrak Daun Gyrinops versteegii. Jurnal Ilmu Teknologi Kayu Tropis, 16(2), 141–149.

Wang, H., 2008. Determination of Genkwanin in the leaves of Aquilaria sinensis (Lour) Gilg. With HPCL. J Trad. Chin. Med. Pharm. 14, 69 – 70

Wang, H., Zhou, M., Lu, J., Yu, B., 2008. Antitumor constituent from leaves of Aquilaria sinensis (Lour) Gilg. Linchan Huazue Yu Gongye, 28, 1 – 5

Wang, S. C., Wang, F., Yue, C. H., 2015. Chemical constituent form the petiole and leaves of Aquilaria sinensis. Biochem. Syst. Ecol. 61, 458 – 461.

Wang, S. C., Wang, F., Yue, C. H., 2015. Chemical constituents from the petioles and leaves of Aquilaria sinensis. Biochem. Syst. Ecol, 61 – 458 – 461

Wangiyana, I. G. A. S., 2019. Medicinal Usage of Agarwood Resin in Form of Essential Oil: A Review. Jurnal Silva Samalas, 2(2), 86–90.

Wangiyana, I. G. A. S., 2020. Development of Agarwood Induction Technology on Agarwood Cultivation-A Review. Jurnal Sangkareang Mataram, 6(1), 29–38.

Wangiyana, I. G. A. S., Isbulloh, F., & Akram., 2020. Perbandingan Aktivitas Antibakteri Ekstrak Kasar Resin dan Daun Gaharu (Gyrinops versteegii). Jurnal Bioteknologi & Biosains Indonesia, 7(1), 28–36.

Wangiyana, I. G. A. S., & Putri, D. S., 2019a. Aplikasi Zat Pengatur Tumbuh dan Kegiatan Pruning Dalam Optimalisasi Budidaya Gaharu Di Desa Duman Kecamatan Lingsar Lombok Barat. Lumbung Inovasi, 4(1), 1–7.

Wangiyana, I. G. A. S., & Putri, D. S., 2019b. Teh Gyrinops : Produk Inovatif dari Istri Petani Desa Duman Kecamatan Lingsar Kabupaten Lombok Barat. Prosiding PEPADU, 1(1), 388–396.

Wangiyana, I. G. A. S., Putri, D. S., & Triandini, I. G. A. A. H., 2019. Pelatihan Pengolahan Daun Gaharu Menjadi Teh Herbal Untuk Istri Petani Anggota Kelompok Tani Desa Duman. Logista Jurnal Ilmiah Pengabdian Kepada Masyarakat, 3(2), 82–89.

Wangiyana, I. G. A. S., & Sami’un., 2018. Characteristic of Agarwood Tea from Gyrinops versteegii Fresh and Dry Leaves. Sangkareang, 4(2).

Wangiyana, I. G. A. S., Sawaludin, Nizar, W. Y., & Wangiyana, W., 2019. Tannin concentrations of Gyrinops tea with different leaf processing methods and addition of herbal medicine ingredients Tannin Concentrations of Gyrinops Tea with Different Leaf Processing Methods and Addition of Herbal Medicine Ingredients. AIP Conference Proceedings, 2199(070012), 1–7.

Wangiyana, I. G. A. S., Triandini, I. G. A. A. H., Putradi, D., & Wangiyana, W., 2018. Tannin Concentration of Gyrinops Tea from Leaves of Juvenile and Mature Agarwood Trees ( Gyrinops versteegii Gilg ( Domke )) with Different Processing Methods. Journal of Chemical and Pharmaceutical Research, 10(10), 113–119.

Wangiyana, I. G. A. S., Wanitaningsih, S. K., & Anggadhania, L., 2020. Pelatihan Teknologi Bio-induksi untuk Petani Gaharu di Desa Pejaring Kabupaten Lombok Timur. Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat, 6(1), 36–44.

Wangiyana, I. G. A. S., Malik, S., 2018. Application of Arbuscular Mycorrhiza from Senaru Forest Rhizosphere for Gyrinops versteegii Germination and Growth. Biosaintifika, 10 (2), 432 - 438.

Wangiyana, I. G. A. S., 2016. Molecular Phylogenetic Analyze of Fusarium from Agarwood and Others Fusarium with Different Type of Nutrition Based on Gen ITS 1. Jurnal Sangkareang Mataram. 2 (1), 1 - 5.

Wangiyana, I G. A. S., 2015. Pemanfaatan Medium Alternatif untuk Pertumbuhan Isolat Fusarium sp. Penginduksi Pembentukan Gaharu pada Gyrinops versteegii (Gilg) Domke. Jurnal Sangkareang Mataram. 1 (3), 54 - 59.

Wei, Z., Bin, N., 2011. GC-MS analysis of the chemical components of the volatile oil from leaves of Aquilaria sinensis (Lour.) Gilg. Med. Plants. 2, 34 – 36.

Xia, F., Sun, J., Jiang, Y., Tu, P., 2013. Further chemical investigation of leaves of Aquilaria sinensis. China J. Chin. Mater. Med. 39, 3299 – 3303.

Yang, M., Liang, Y., Chen, H., Huang, Y., Gong, H., 2014. Isolation and identification of the chemical constituent in ethyl acetate extracts of wild Aquilaria sinensis leaves. Modern Food Sci. Technol. 31, 128 – 163.

Yu, Q., Qi, J., Yu, H. X., Chen, L. L., Kou, J. P. , Liu, S. J., Yu, B. Y., 2013. Qualitative and quantitative analysis of phenolic compounds in the leaves of Aquilaria sinensis using liquid chromatography mass spectrometry. Phytochem. Anal. 24, 349 – 356.

Zhou, M., Wang, H., Kou, J., Yu, B., 2008. Antinocieptive and anti-inflammatory activities of Aquilaria sinensis (Lour.) Gilg. Leaves extract. J. Ethnopharmacol. 117, 345 – 350.

Zulkifle, N. L. B., 2018. Antidiabetic Activity of Aquilaria malaccensis (Agarwood) Leaves Extracts. Thesis. Universiti Malaysia Pahang.




DOI: https://doi.org/10.33394/jss.v3i1.3681

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