Pengaruh Ekstrak Tembuluk Kelapa Merah (Cocos nucifera var. rubescens) Terhadap Penurunan Kadar Glukosa Darah Pada Mencit (Mus musculus)

Winda Cinthia Novi, Sutrisnawati Sutrisnawati, Achmad Ramadhan, Manap Trianto, Masrianih Masrianih, I Negah Kundera

Abstract


This study aims to determine the effect of red coconut embryo extract (Cocos nucifera var. rubescens) on reducing blood glucose levels in mice (Mus musculus). The research employed a true experimental method using a completely randomized design (CRD). A total of 24 mice were used, divided into 6 groups with 5 replications each. The normal control group (KN) was given food and water ad libitum, while the positive control (K+), negative control (K−), and treatment groups (PI, PII, PIII) were induced with alloxan for 7 days. The positive control group (K+) was administered 1.3 mg of synthetic metformin per 20 grams of body weight. Both the normal control (KN) and negative control (K−) groups were given food and water ad libitum. The treatment groups PI, PII, and PIII were administered red coconut embryo extract at varying concentrations. Treatment group 1 (PI) received 40% extract, group 2 (PII) received 60%, and group 3 (PIII) received 80%. Observation data were analyzed using ANOVA. The results showed that the red coconut embryo extract had a significant effect on reducing blood glucose levels in alloxan-induced mice. The most effective concentration was 40% (PI), with an average blood glucose level of 98.6 mg/dL.

Keywords


Tembuluk kelapa merah (Cocos nucifera var. rubescens); glukosa darah; Mencit (Mus musculus)

Full Text:

PDF

References


Abdillah, F. M. (2023). Prospek kelapa wulung genjah dari segi pariwisata dan kesehatan di Desa Kuripan Selatan (Vol. 1, Oktober 2023).

Blanter, M., Sork, H., Tuomela, S., et al. (2019). Genetic and environmental interaction in type 1 diabetes: A relationship between genetic risk alleles and molecular traits of enterovirus infection. Current Diabetes Reports, 19(9), 82. https://doi.org/10.1007/s11892-019-1200-5

Care, D., & Suppl, S. S. (2022). Classification and diagnosis of diabetes: Standards of medical care in diabetes—2022. Diabetes Care, 45(Suppl), 517–538. https://doi.org/10.2337/dc22-S002

Dalimartha, S. (2008). Atlas tumbuhan obat Indonesia (Jilid 5). Pustaka Bunda.

Datu, O. S. (2022). Efek pemberian ekstrak buah salak (Salacca zalacca) dalam menurunkan kadar glukosa darah pada tikus model diabetes melitus. Jurnal MIPA, 12(1), 30–33.

Fauziah, N., Yuliawati, K. M., & Kodir, R. A. (2019). Pengujian aktivitas antibakteri dari sabut kelapa hijau (Cocos nucifera L Var. Rubencens) dan sabut kelapa biasa (Cocos nucifera L) terhadap Propionibacterium acnes. Prosiding Farmasi, 5(2), 489–495.

Kawau, D. S., Pakasi, C. B. D., Sondakh, M. L., & Rengkung, L. R. (2015). Kajian pendapatan usaha tani kelapa dengan diversifikasi horizontal pada Gapoktan Petani Jaya di Desa Poigar 1 Kecamatan Sinonsayang Kabupaten Minahasa Selatan. Agri Sosio Ekonomi, 11(3), 41–52.

Khin, P. P., Lee, J. H., & Jun, H. S. (2023). Pancreatic beta-cell dysfunction in type 2 diabetes. European Journal of Inflammation, 21, 1–13. https://doi.org/10.1177/1721727X231162657

Kurniawati, E., & Sianturi, C. Y. (2016). Manfaat sarang semut (Myrmecodia pendans) sebagai terapi antidiabetes. Majority, 5(2), 101–106.

Ludong, R. M., De Queljoe, E., & Simbala, H. E. I. (2019). Uji efektivitas ekstrak buah pinang yaki (Areca vestiaria) terhadap penurunan kadar gula darah tikus putih jantan galur Wistar (Rattus norvegicus) yang diinduksi aloksan. Pharmacon, 8(2), 416–423.

Murtiningsih, M. K., Pandelaki, K., & Sedli, B. P. (2021). Gaya hidup sebagai faktor risiko diabetes melitus tipe 2. E-CliniC, 9(2), 328–336.

Ocktarini, R., Prasetyo, D. H., & Sjarifah, I. (2011). Pengaruh ekstrak herba anting-anting (Acalypha australis) terhadap kadar glukosa darah mencit Balb/C dengan induksi streptozotocin. Biofarmasi, 9(1), 12–16.

Oswari, L. D., & Aldrich, S. (2021). Uji aktivitas penghambatan enzim α-glukosidase ekstrak air dan ekstrak etanol kayu kuning (Arcangelisia flava). Bio Kimia FMIPA Universitas Sriwijaya, 8(1), 1–9.

Pratiwi, E., Putri, A. S., & Gunantar, D. A. (2020). Pengaruh suhu pengeringan pada pembuatan kelapa parut kering (Desiccated coconut) terhadap sifat kimia dan organoleptik. Jurnal Teknologi Pangan dan Hasil Pertanian, 15(2), 10–18.

Putra, M. A. D., Jannah, S. N., & Sitasiwi, A. J. (2020). Uji aktivitas antidiabetes cuka kulit nanas (Ananas comosus L. Merr.) pada tikus putih (Rattus norvegicus) jantan galur Wistar yang diinduksi aloksan. Jurnal Pro-Life, 7(2), 188–197.

Setiadi, E., Peniati, E., & Susanti, R. (2020). Pengaruh ekstrak kulit lidah buaya terhadap kadar gula darah dan gambaran histopatologi pankreas tikus yang diinduksi aloksan. Life Science, 9(2), 171–185.

Sulistijo, S. A. (2021). Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia—2021 (Penerbit PB. PERKENI). PERKENI.

Supriani, Harira, L. W., & Fadlilah, N. M. (2021). Pemanfaatan obat tradisional untuk pemeliharaan kesehatan, pencegahan penyakit, dan perawatan kesehatan di era pandemi Covid-19 dengan ramuan bersumber dari Kemenkes RI. Jurnal Global Health Science Group, 1, 23–26.

Syakrawi, M., & Dora, N. (2024). Pengobatan tradisional bluluk dalam menetralisir penyakit diabetes menurut perspektif masyarakat Jawa. Jurnal Pengobatan Tradisional Nusantara, 1, 1–8.

Yuli Wahyu Tri Mulyani, H., Rahayu, L., & Wulandari, D. (2021). Efek antidiare fraksi etanol bakal buah kelapa (Cocos nucifera L) terhadap mencit putih (Mus musculus). Universitas Muhammadiyah Metro.




DOI: https://doi.org/10.33394/bioscientist.v13i2.16418

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Creative Commons License
Bioscientist : Jurnal Ilmiah Biologi is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License

Editorial Address: Pemuda Street No. 59A, Catur Building Floor I, Mataram City, West Nusa Tenggara Province, Indonesia