Jumlah Eritrosit Tikus Putih (Rattus norvegicus) Strain Wistar Bunting yang Mengonsumsi MSG Organik dan Sintetis
Abstract
This study aims to determine the number of erythrocytes in pregnant Wistar strain white rats (Rattus norvegicus) consuming organic and synthetic MSG. This study used a Completely Randomized Design (CRD) with 21 samples, 7 treatments, and 3 replications; control treatment (normal feed), P1 (60 mg/kgBW organic MSG), P2 (120 mg/kgBW organic MSG), P3 (240 mg/kgBW organic MSG), P4 (60 mg/kgBW synthetic MSG), P5 (120 mg/kgBW synthetic MSG), and P6 (240 mg/kgBW synthetic MSG). The analysis includes the number of erythrocytes in white rats (Rattus norvegicus), One Way ANOVA test using SPSS version 29, followed by Duncan's Multiple Range Test (DMRT) to determine the mean differences between treatments. The research results show that the number of erythrocytes in the control group (normal) was 6.97 x 106 / µL, P1 (5.17 x 106 / µL), P2 (5.37 x 106 / µL), P3 (5.89 x 106 / µL), P4 (7.61 x 106 / µL), P5 (7.90 x 106 / µL), and P6 (8.29 x 106 / µL). Thus, the administration of organic and synthetic MSG affects the number of erythrocytes in pregnant white rats (Rattus norvegicus) of the Wistar strain, marked by an increase in the number of erythrocytes. The lowest number of erythrocytes was in P1 (60 mg/kgBB), and the highest number of erythrocytes was in P6 (240 mg/kgBB).
Keywords
Full Text:
PDFReferences
Anggitasari, A., & Setyaningsih, E. (2023). Number of Erythrocytes of White Rats (Rattus norvegicus) Sonded with a Combination of Porang Tuber and Moringa Leaf Extract. International Conference on Biology Education, Natural Science, and Technology (INCOBEST), 1(1), 375-383.
Ayudia, T. (2020). Sistem Pakar Diagnosa Penyakit Akibat Konsumsi Berlebihan Monosodium Glutamat (MSG) Menggunakan Metode Anfis. Jurnal Pelita Informatika, 8(3), 382-388. Retrieved from https://api.semanticscholar.org/CorpusID:229054816
Ayuna, D. N. (2020). Pengaruh Pemberian Monosodium Glutamat (MSG) Peroral Terhadap Nekrosishepatosit Tikus Putih (Rattus norvegicus) Jantan Galur Wistar. Jurnal Kedokteran Nanggroe Medika, 4(1), 1-8.
Barnett, S. A. (1976). The Rat: A Study in Behavior. Canberra: Australian National University Press. doi:10.4324/9781315134468
Bera, T. K., & et al. (2017). Effects of Monosodium Glutamate on Human Health: A Systematic Review. World Journal of Pharmaceutical Sciences, 5(5), 139-144. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/effects-monosodium-glutamate-human-health-review
Chaparro, C. M., & Suchdev, P. S. (2019). Anemia Epidemiology, Pathophysiology, and Etiology in Low- and Middle-Income Countries. Annals Of The New York Academy Of Sciences, 1450(1), 15-31. doi:https://doi.org/10.1111/nyas.14092
Fauziah, D. E., & et al. (2025). Gambaran Histologi Ginjal Tikus Putih (Rattus norvegicus) Bunting yang Mengkonsumsi MSG Organik dan MSG Sintetis. BioEksakta: Jurnal Ilmiah Biologi Unsoed, 7(1), 52-59. doi: https://jos.unsoed.ac.id/index.php/bioe/article/view/13968/6553
Food and Drug Administration. (2012). Question and Answers on Monosodium
Gwozdzinski, L., & et al. (2023). Diosmin and Bromelain Stimulate Glutathione and Total Thiols Production in Red Blood Cells. Molecules, 28(5), 1-13. doi:https://doi.org/10.3390/molecules28052291
He, Q., & et al. (2017). Sex-Specific Reference Intervals of Hematologic and Biochemical Analytes in Sprague-Dawley Rats Using The Nonparametric Rank Percentile Method. PLOS ONE, 12(12), 1-18. doi:https://doi.org/10.1371/journal.pone.0189837
Kartolo, W. (1993). Prinsip-Prinsip Fisiologi Hewan. Jakarta: Proyek Pembinaan Tenaga Kependidikan Pendidikan Tinggi.
Kurtanty, D., Faqih, D. M., & Upa, N. P. (2018). Review Monosodium Glutamat: How To Understand It Properly (IV ed.). Jakarta: Primer Koperasi Ikatan Dokter Indonesia.
Laeto, A. B., & et al. (2022). Analisis Profil Eritrosit Tikus Putih (Rattus norvegicus) Pasca Diet Vegetarian. Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton, 8(1), 107-118. doi:https://doi.org/10.35326/pencerah.v8i1.1901
Mulyani, E. Y. (2019). Metabolisme Ibu Hamil. Jakarta: University Press UEU.
Munasiah, M. (2020). Dampak Pemberian Monosodium Glutamat Terhadap Kesehatan. Jurnal Penelitian Perawat Profesional, 2(4), 51 – 458. http://jurnal.globalhealthsciencegroup.com/index.php/JPPP
Porsche, D., Tulenan, V., & Sugiarso, B. A. (2019). Aplikasi Pembelajaran Interaktif Sistem Peredaran Darah Manusia Untuk Kelas 5 Sekolah Dasar. Jurnal Teknik Informatika, 14(2), 172-183. https://doi.org/10.35793/jti.v14i2.23992
Pujiansyah, Parwati, W. D., & Rahayu, E. (2018). Pengaruh Monosodium Glutamat Sebagai Pupuk Alternatif Serta Cara Pemberiannya Terhadap Pertumbuhan Bibit Kelapa Sawit Pre Nursery. Jurnal Agromast, 3(1), 1-10.
Radosinska, J., & et al. (2023). Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties. Biology, 12(1030), 1-17. doi:https://doi.org/10.3390/biology12071030
Rahayu, A., & Elieser. (2018). Analisis Jumlah Sel Eritrosit Darah Tikus Putih Jantan (Rattus norvegicus) Strain Wistar Sebelum dan Setelah Perlakuan Ekstrak Buah Merah (Pandanus conoideus). Jurnal Biologi Papua, 10(1), 32-37. https://doi.org/10.31957/jbp.134
Rahman , M., & Yang, D. (2018). Effects of Ananas comosus Leaf Powder On Broiler Performance, Haematology, Biochemistry, and Gut Microbial Population. Revista Brasileira de Zootecnia, 47. doi:https://doi.org/10.1590/rbz4720170064
Restuti, A. N., Yulianti, A., & Lindawati, D. (2020). Efek Minuman Cokelat (Theobroma cacao L.) Terhadap Peningkatan Jumlah Eritrosit Dan Kadar Hemoglobin Tikus Putih Anemia . Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition), 8(2), 79-84. Retrieved from https://ejournal.undip.ac.id/index.php/jgi/
Rochmah, D. L., & Utami, L. T. (2022). Dampak Mengonsumsi Monosodium Glutamat (MSG) Dalam Perkembangan Otak Anak. Jurnal Kesehatan Masyarakat, 10(2), 163-166. doi:https://doi.org/10.14710/jkm.v10i2.32473
Rosida, A., & Hendriyono. (2015). Nilai Rujukan Hematologi Orang Dewasa Normal Di RSUD Ulin Banjarmasin. Berkala Kedokteran, 11(1), 101-109. doi:https://doi.org/10.20527/JBK.V11I1.190
Santoso, A. (2023). Rumus Slovin: Panacea Masalah Ukuran Sampel? Jurnal Psikologi Universitas Sanata Dharma, 4(2), 24-43. doi:https://doi.org/10.24071/suksma.v4i2.6434
Shosha, H. M., & et al. (2023). Effect of Monosodium Glutamate on Fetal Development and Progesterone Level in Pregnant Wistar Albino Rats. Environmental Science and Pollution Research , 30, 49779–49797. doi:https://doi.org/10.1007/s11356-023-25661-x
Sundaya, L., & et al. (2016). Analisis Jumlah Eritrosit Pada Darah Hewan Coba Tikus Putih Jantan (Rattus novergicus) Strain Wistar Sebelum dan Setelah Pemberian Filtrat Tanaman Pakis Sayur (Diplazium esculentum). Jurnal Kedokteran, 1(2), 203-213. Retrieved from https://e-journal.unizar.ac.id/index.php/kedokteran/article/view/600
Tangkas, P. J., Suarsana, I., & Gunawan, I. N. (2021). Profil Hematologi Tikus Putih yang Diberi Latihan Intensif dan Ekstrak Kulit Pisang Kepok. Buletin Veteriner Udayana, 13(2), 206-216. doi:10.24843/bulvet.2021.v13.i02.p013
Vigneshwar, R., & et al. (2021). Sex-specific Reference Intervals For Wistar Albino Rats: Hematology and Clinical Biochemistry. Indian J Anim Health , 60(1), 58-65. doi:https://doi.org/10.36062/ijah.60.1.2021.58-65
Wang, S., Zhang, S., & Adhikari, K. (2019). Influence od Monosodium Glutamate and Its Substitutes on Sensory Characteristics and Consumer Perceptions of Chicken Soup. Foods, 8(2), 1-71. doi:https://www.mdpi.com/2304-8158/8/2/71
Weber, B., & et al. (2019). Modeling Trauma in Rats: Similarities to Humans and Potential Pitfalls to Consider. Journal of Translational Medicine, 17(305), 1-19. https://doi.org/10.1186/s12967-019-2052-7
Wicaksono, M., & et al. (2022). Potential Bromelain Pinneapple Extract to Breaker Tempe Protein As Organic MSG . Asian Journal of Health and Applied Sciences (AJHAS) , 1(3), 11-21. doi:https://doi.org/10.53402/ajhas.v1i3.182
Wicaksono, M., Dhimas P, K., Salsabila, A., & Tias, E. (2022). Hidrolisat Tempe Dengan Bromelain Ekstrak Nanas Sebagai Inovasi MSG Organik. https://eprints.ums.ac.id/id/eprint/101424%0Ahttps://eprints.ums.ac.id/10142 4/1/A420200026 M Galih Wicaksono.pdf.
Wiyono, A., & Mustofani, D. (2019). Efektivitas Gel Ekstrak Kasar Bromelin Kulit Nanas (Ananas comosus L. merr) Hasil Optimasi Formula Pada Tikus Yang Dibuat Luka Memar. As-Syifaa Jurnal Farmasi, 11(2), 112-123. doi:https://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view
Yonata, A., & Iswara, I. (2016). Efek Toksik Konsumsi Monosodium Glutamate. Majority, 5(3), 100-104. http://repository.lppm.unila.ac.id/22691/1/1044-1594-1-PB.pdf
Zanfirescu, A., & et al. (2019). A Review of The Alleged Health Hazards of Monosodium Glutamate. Compr Rev Food Sci Food Saf, 18(4), 1111–1134. doi:https://ift.onlinelibrary.wiley.com/doi/10.1111/1541-4337.12448
Zuraidawati, Darmawi, & Sugito. (2018). Jumlah Leukosit dan Eritrosit Tikus Putih (Rattus norvegicus) yang Diberi Ekstrak Etanol Bunga Sirsak (Annona muricata L.). Prosiding Seminar Nasional Biotik, 588-593. doi:https://dx.doi.org/10.22373/pbio.v6i1.4300
DOI: https://doi.org/10.33394/bioscientist.v13i1.15109
Refbacks
- There are currently no refbacks.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Bioscientist : Jurnal Ilmiah Biologi is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License
Editorial Address: Pemuda Street No. 59A, Catur Building Floor I, Mataram City, West Nusa Tenggara Province, Indonesia